RESUMEN Aedes aegypti L. es el mosquito que transmite el virus de la fiebre amarilla, el dengue, el zika y el chikungunya. La prevención y el control de tales enfermedades generalmente dependen del uso de productos químicos, que causan daños al hombre y al medio ambiente. Por ello, los aceites vegetales con acción larvicida se utilizan como alternativa para controlar este insecto. El objetivo de este trabajo fue evaluar el potencial larvicida de aceites vegetales de Caryocar coriaceum, Mauritia flexuosa, Carapa guianensis, Copaifera langsdorffii, Ricinus communis y Cocos nucifera contra A. aegypti. El experimento se dividió en dos bioensayos. En el primero se realizó un diseño completamente al azar con siete tratamientos (seis aceites vegetales a 500 ppm y un control y cuatro repeticiones). Se evaluó el número de larvas muertas a las 24, 48, 72, 96 y 120 h de exposición. En el segundo bioensayo, se utilizaron los aceites vegetales más eficientes (C. coriaceum y M. flexuosa) en concentraciones 0, 500, 1000, 1500, 2000 y 2500 ppm, con cuatro repeticiones. El número de larvas muertas se evaluó según el primer bioensayo. Todos los aceites utilizados tienen efecto larvicida sobre larvas de A. aegypti de tercer estadio, con mayor eficacia a las 120 h de exposición. Los aceites de C. coriaceum y M. flexuosa mostraron mejor eficacia en el control de larvas, siendo la dosis de 2500 ppm la más recomendada. El LD10, LD50 y LD90 del aceite de M. flexuosa recomendado para controlar larvas son 234, 648 y 1794 ppm, respectivamente.

ABSTRACT Aedes aegyptiL. is the mosquito vector of yellow fever, dengue, zika, and chikungunya viruses. The prevention and control of such diseases usually rely on the use of chemicals, that can cause harm to human health and the environment. Vegetable oils with larvicidal activity are used as an alternative tool to control this insect. This study aimed to evaluate the larvicidal activity of vegetable oils fromCaryocar coriaceum,Mauritia fIexuosa,Carapa guianensis, Copaifera langsdorffii, Ricinus communisandCocos nuciferaagainstA. aegypti larvae. The experiment was divided into two bioassays. In the first, a completely randomized design was used with seven treatments (six vegetable oils at 500 ppm and one control with four replications). The number of dead larvae was evaluated 24, 48, 72, 96, and 120 h after exposure. In the second bioassay, the most efficient vegetable oils from the first bioassay (C. coriaceumandM. flexuosa) were used at the concentrations of 0, 500, 1000, 1500, 2000, and 2500 ppm, with four replications. The number of dead larvae was evaluated according to the first bioassay. All oils used had larvicidal activity on third-instar stage larvae ofA. aegypti, with greater efficiency 120 h after exposure. The oils ofC. coriaceumandM. flexuosaat 2500 ppm had the best efficacy in the larvae control. The LD10, LD50, and LD90 ofM. flexuosaoil recommended for controlling larvae are 234, 648, and 1794 ppm, respectively.

Resumo: Introdução: A residência médica representa um momento desafiador, com elevado nível de exigência e necessidade de desenvolvimento de inúmeras competências pessoais e profissionais. Com base nisso, implantou-se, em abril de 2019, um programa de mentoria inédito para 30 residentes de clínica médica, buscando oferecer suporte pessoal e estimular desenvolvimento profissional. Relato de experiência: O programa de mentoria foi estruturado em abril de 2019, com 30 residentes de clínica médica e seis mentores com experiência em preceptoria clínica. Com duração de 11 meses, o programa abordou temas não usualmente discutidos na formação desses especialistas, como profissionalismo, empatia, burnout e qualidade de vida, gestão de tempo, gestão de conflitos e role-model. Os encontros ocorriam mensalmente, com local definido pelo grupo. Após o fim da atividade, foi realizada pesquisa de opinião utilizando questionário padronizado com respostas em escala Likert para avaliação de relevância dos temas discutidos e impacto na prática dos médicos residentes. Obtiveram-se 90% de respostas, nas quais se destacou a relevância dos temas burnout e qualidade de vida e empatia. Dos residentes, 96,3% afirmaram que as discussões mudaram a forma deles de pensar e agir profissionalmente. Destacaram que o mentoring “abria a mente acerca de diversidade de opiniões, permitindo crescimento pessoal e profissional” e que “Gerir o tempo, conflitos, burnout estão presentes no nosso dia a dia e também fazem parte da medicina que praticamos”, pontuando dificuldade de consenso entre os membros do grupo para definição do horário e dia a ser realizada a reunião. A atividade demonstrou avaliação positiva dos mentorados. Discussão: Na formação de um médico residente, o programa de mentoria melhora a autoconfiança e promove um impacto positivo na carreira profissional apesar das dificuldades enfrentadas. A mentoria funciona ainda como suporte psicossocial, pois cria-se um livre acesso entre residente e preceptor, o que culmina, na nossa avaliação, em uma excelente relação entre mentores e mentorados. Conclusão: No Ceará, o programa de mentoring para os residentes de clínica médica foi inédito. Houve efeito positivo, em que temas importantes foram discutidos com mais profundidade, com maior crescimento pessoal e profissional. Os autores sugerem que o mentoring seja mantido e incluído como atividade essencial no currículo dos programas de residência médica.

Abstract: Introduction: Medical residency represents a challenging moment, with a high level of demand and the need to develop several personal and professional skills. Therefore, in April 2019, the unprecedented mentoring program for thirty internal medicine residents was implemented, seeking to offer personal support and encourage professional development. Experience Report: A mentoring program was structured in April 2019, lasting 11 months, consisting of 30 internal medicine residents and 6 mentors with experience in clinical preceptorship, covering topics that are not usually discussed in the training of these specialists, such as professionalism, empathy, burnout and quality of life, time management, conflict management and role-model. The meetings took place monthly, in a location defined by the group. After the end of the activity, an opinion poll was conducted using a standardized questionnaire with answers arranged on a Likert scale to assess the relevance of the discussed topics and the impact on the medical residents’ practice. A 90% response rate was obtained, highlighting the relevance of the topic Burnout and quality of life and empathy. A total of 96.3% of residents stated that the program changed their mind about their professional behavior. They declared that mentoring “opened their mind about the diversity of opinions, allowing personal and professional growth” and that “to manage time, conflicts, burnout are present in our daily lives and are also part of the medicine we practice”. However, there were complaints about some difficulties among the group members to define the time and day when the meetings should be held. In summary, the activity had a positive evaluation from the mentees. Discussion: There is a positive impact of the mentoring program on the training of a resident doctor, improving self-confidence and having a positive impact on the professional career despite the faced difficulties. Mentoring also serves as a psychosocial support, creating free access between the resident and the preceptor, culminating, based on our evaluation, in an excellent relationship between mentors and mentees. Conclusion: In Ceará, the mentoring program for internal medicine residents was unprecedented. There is a positive effect, in which important topics were discussed in more depth, with greater personal and professional growth. We suggest that mentoring be maintained and included as an essential activity in the curriculum of Medical Residency Programs.

Abstract Background: The Functional Index for Hand Osteoarthritis (FIHOA) is a simple, reliable, and reproducible specific instrument to evaluate hand OA that can be applied both in clinical practice and research protocols. In order to be used in Brazil, FIHOA has to be translated into Portuguese, culturally adapted and have the reliability of the translated FIHOA version tested, which is the purpose of this study. Methods: The FIHOA was translated into Brazilian Portuguese and administered to 68 patients with hand OA recruited between May 2019 and February 2020. The test-retest was applied to 32 patients and the reliability was assessed using Spearman’s correlation coefficient and intraclass correlation coefficient (ICC). The internal consistency reliability was evaluated using Cronbach’s alpha. External construction validity was assessed using the Spearman’s correlation test between FIHOA and pain, assessed with a Visual Analogue Scale (VAS), the Cochin Hand Functional Scale (CHFS) and Health Assessment Questionnaire (HAQ). Results: The 30 participants that initially answered the translated version of the FiHOA did not report difficulties in understanding or interpreting the translated version. The test-retest reliability for the total score was strong ( r =0.86; ICC = 0.89). Mean differences (1.37 ± 0.68) using Bland Altman’s analysis did not significantly differ from zero and no systematic bias was observed. Cronbach’s alpha was also high (0.89) suggesting a strong internal coherence in the test items. There were also correlations between FIHOA and the CHFS ( r =0.88), HAQ ( r = 0.64) and pain in the hands both at rest ( r =0.55) and in motion ( r =0.44). Conclusion: The translation of the FIHOA into Brazilian Portuguese proved a valid instrument for measuring the functional capacity of patients with hand OA who understand Brazilian Portuguese.

Resumo: As relações contemporâneas entre turismo e desenvolvimento têm destacado a abordagem estruturada em redes sociais, a qual também tem sido estimulada pelas políticas públicas, que por meio de diversos atores representativos possam gerir as ações da comunidade local. Deste modo, este artigo tem como objetivo analisar o nível de relação de uma rede de turismo na perspectiva do desenvolvimento local, utilizando a teoria de redes (Rovere, 1999) e a de desenvolvimento local (Barquero, 2001; Boisier, 1996; Sen, 2000). A compreensão da pesquisa se deu a partir da relação e da interação dos participantes do processo de decisão da rede política estadual do turismo do Rio Grande do Norte, que compõe o Conselho Estadual de Turismo (Conetur). Para tanto, o estudo contou com a coleta de dados do tipo bibliográfica, documental, baseada nas atas e no Regimento de criação do conselho e entrevistas com os membros integrantes, utilizando uma abordagem qualitativa. Os resultados apresentados tiveram como base a análise de conteúdo do tipo estruturadora temática. Os principais resultados da pesquisa evidenciam que a rede de governança se configura com o baixo nível de relação, não a reconhecendo como um parceiro, caracterizada pelas inúmeras divergências e incongruências formadas no território, dificultando ações de desenvolvimento local. Limitações e sugestões da pesquisa também foram apontadas.

Abstract: Contemporary relations between tourism and development have focused on the structured approach in social networks, which has also been stimulated by public policies that, through various representative actors, can manage the actions of the local community. In this way, this article aims to analyze the level of relationship of a tourism network in the perspective of local development, using network theory (Rovere, 1999) and local development theory (Barquero, 2001; Boisier, 1996; Sen, 2000). The understanding of the research was based on the relationship and interaction of participants in the decision-making process of the state tourism policy network of Rio Grande do Norte, which comprises the State Tourism Council (CONETUR). To do so, the study included bibliographical data collection, document based on the minutes and Board creation regiment and interviews with the members, using a qualitative approach. The results were analyzed by means of content analysis of the thematic type. The main results of the research show that the network of governance is configured with the low level of relationship not recognizing it as a partner, characterized by the numerous divergences and inconsistencies formed in the territory, making local development actions difficult. Limitations and suggestions of the research are also pointed out.

RESUMEN: Las relaciones contemporáneas entre el turismo y el desarrollo han resaltado el enfoque estructurado en las redes sociales, que también ha sido estimulado por las políticas públicas, que a través de diversos actores representativos, pueden gestionar las acciones de la comunidad local. Por lo tanto, este artículo tiene como objetivo analizar el nivel de relación de una red de turismo en la perspectiva del desarrollo local, utilizando la teoría de las redes (Rovere, 1999) y la del desarrollo local (Barquero, 2001; Boisier, 1996; Sen, 2000). La comprensión de la investigación se basó en la relación e interacción de los participantes en el proceso de toma de decisiones de la red política estatal de turismo en Rio Grande do Norte, que conforma el Consejo de Turismo del Estado (Conetur). Para este fin, el estúdio incluyó la recopilación de datos de un tipo documental bibliográfico basado en las actas y las Reglas de creación del consejo y entrevistas con los miembros, utilizando un enfoque cualitativo. Los resultados presentados se basaron en el análisis de contenido del tipo de estructuración temática. Los principales resultados de la investigación muestran que la red de gobernanza está configurada con un bajo nivel de relación, sin reconocerla como socio, caracterizada por las innumerables divergencias e incongruencias formadas en el territorio, lo que dificulta las acciones de desarrollo local. También se señalaron limitaciones y sugerencias de investigación.

Resumo A introdução da agricultura nas cidades é um dos eixos prioritários atuais para a reforma ambiental urbana. Existe um amplo consenso a esse respeito, principalmente devido à melhoria do equilíbrio dos ecossistemas urbanos. Ademais, a agricultura urbana também oferece várias possibilidades para a sociedade, na medida em que pode contribuir para a solução de situações de pobreza urbana, além de melhorar a saúde pública dos bairros onde está localizada, principalmente com base em princípios ecológicos. Além de outras vantagens que envolvem diretamente a população que pratica a agricultura ou que a possui como fonte de alimento. Dessa maneira, a agricultura urbana ajuda a mitigar a dupla dimensão socioambiental da crise ecológica planetária de nosso tempo. Nesse sentido, este estudo visa aprofundar a discussão sobre a dimensão social da agricultura urbana, problematizando experiências de diferentes cidades do mundo (particularmente Barcelona, Girona e Natal), esta última a título de contextualização, propondo um esquema dos diferentes tipos de vantagens que essa apresenta. A conclusão aponta na direção de um fenômeno social marcado pela resistência territorial e pela transição para um paradigma produtivo mais equilibrado e contra-racional, em oposição ao paradigma capitalista totalitário globalizado.

Abstract The introduction of agriculture in cities is one of the current priority axes for urban environmental reform. There is a broad consensus in this regard, largely because of the improvement of urban ecosystem balances. However, urban agriculture also offers various possibilities for society to the extent that it can contribute to solving urban poverty situations, while improving the public health of the neighborhoods where it is located, especially based on ecological principles. In addition to other advantages that directly involve the population that practices agriculture or that has it as a food source. In this way, urban agriculture helps mitigate the double socio-environmental dimension of the planetary ecological crisis of our time. In this sense, this study aims to deepen the social dimension of urban agriculture by problematizing experiences of different cities in the world (particularly Barcelona, Girona and Natal), the latter as contextualization, proposing a scheme of the different types of advantages that it entails. The conclusion points in the direction of a social phenomenon marked by territorial resistance and transition towards a more balanced and counter-rational productive paradigm opposed to the globalized totalitarian capitalist paradigm.

Resumen La introducción de la agricultura en las ciudades es uno de los ejes prioritarios actuales para la reforma ambiental urbana. Existe un amplio consenso al respecto, principalmente debido al mejor equilibrio de los ecosistemas urbanos. Además, la agricultura urbana también ofrece varias posibilidades para la sociedad, ya que puede contribuir a la solución de situaciones de pobreza urbana, además de mejorar la salud pública de los barrios donde se ubica, principalmente sobre la base de principios ecológicos. Además de otras ventajas que involucran directamente a la población que practica la agricultura o que la tiene como fuente de alimento. De esta forma, la agricultura urbana ayuda a mitigar la doble dimensión socioambiental de la crisis ecológica planetaria de nuestro tiempo. En este sentido, este estudio tiene como objetivo profundizar la discusión sobre la dimensión social de la agricultura urbana, problematizar las experiencias de diferentes ciudades del mundo (particularmente Barcelona, Girona y Natal), esta última a título de contextualización, además de proponer un esquema de los diferentes tipos de ventajas que presenta. La conclusión apunta hacia un fenómeno social marcado por la resistencia territorial y la transición a un paradigma productivo más equilibrado y contrarracional, en oposición al paradigma capitalista totalitario globalizado.

ABSTRACT Objective: To evaluate the effect of meditation on the psychological stress level of women with breast cancer. Method: A systematic literature review performed in the LILACS, PubMed, Scopus, CINAHL and Web of Science databases. Results: The sample consisted of 22 studies using Mindfulness, Transcendental Meditation, and Contemplative Self-Healing Meditation techniques. There was a significant effect of meditation on stress reduction, post-traumatic stress symptoms, self-reported stress, and chronic stress verified. In some studies, the effect was associated with decreased cortisol and increased telomerase. Conclusion: Meditation has shown positive effects in reducing physical and emotional symptoms such as psychological stress, depression, anxiety, fatigue, fear of recurrence and rumination, representing an efficient strategy for coping with the disease and improving quality of life.

RESUMEN Objetivo: Evaluar el efecto de la meditación en el nivel de estrés psicológico de mujeres con neoplasia mamaria. Método: Revisión sistemática de la literatura, realizada en las bases de datos LILACS, PubMed, Scopus, CINAHL y Web of Science. Resultados: La muestra estuvo compuesta de 22 estudios que emplearon las técnicas Mindfulness, Meditación Transcendental, Meditación Contemplativa de autocuración. Se verificó efecto significativo de la medicación en la reducción del nivel de estrés, los síntomas de estrés postraumático, autorrelato de estrés y estrés crónico. En algunos estudios, el efecto estuvo asociado con la reducción del cortisol y el aumento de la telomerasa. Conclusión: La meditación presentó efectos positivos en la reducción de síntomas físicos y emotivos, como el estrés psicológico, depresión, ansiedad, fatiga, miedo de recidiva y rumiación, representando estrategia eficiente para enfrentamiento de la enfermedad y mejoría de la calidad de vida.

RESUMO Objetivo: Avaliar o efeito da meditação no nível de estresse psicológico de mulheres com neoplasia mamária. Método: Revisão sistemática da literatura, realizada nas bases de dados LILACS, PubMed, Scopus, CINAHL e Web of Science. Resultados: A amostra foi composta de 22 estudos que empregaram as técnicas Mindfulness, Meditação Transcendental, Meditação Contemplativa de autocura. Verificou-se efeito significativo da meditação na redução do nível de estresse, nos sintomas de estresse pós-traumático, autorrelato de estresse e estresse crônico. Em alguns estudos, o efeito esteve associado à redução do cortisol e ao aumento da telomerase. Conclusão: A meditação apresentou efeitos positivos na redução de sintomas físicos e emocionais, como o estresse psicológico, depressão, ansiedade, fadiga, medo de recorrência e ruminação, representando estratégia eficiente para enfrentamento da doença e melhoria da qualidade de vida.

Tourism is a sócio-spatial phenomenon that articulates diferent interfaces (economic, social, and environmental), which enables it to be the subject of research in different sciences, including Geography, the focus of this artlcle. Similarly, the historical tendency of Geography stands out in analyzing deverse themes, conditioned to the new rationalities put in the space. Thus, in order to broaden the cooperation between researchers (turismologists and geographers), the general objective is to map the studies (theses and dissertations) that opt to tourism as a research topic, within the scope of the Brazilian postgraduate programs strictu sensu in Geography, and to analyze the relevance of the tourism theme to the research work. Methodlogically, the exploratory-analytical character is highlighted, permeated by a qualitative approach, highlighing the bibliographic survey and content analysis as technical tools. The results show a total of 814 studies (theses and dissertations) that opt-in the thematic of tourism, within the scope of stricto sensu postgraduate in Geography in Brazil, where 641 are dissertation and 173 are theses, It is also worth noting that 491 studies chose tourism as the central theme of the reserch, and 323 studies treated tourism in a way complementary to the scope of research. It is concluded that tourism as thematic for studies (theses and dissertations) of the Brazlian graduate programs stricto sensu in Geography, is relevant, and Geography continues to stand out as one of the sciences that most foments studies based on the academic relation with tourism. The perspective is tha the studies advance in number and in complexity of the problematized questions.

El turismo es un fenómeno socio-espacial que articula distintas relaciones (económica, social, ambiental), particularidad que lo habilita como temática de investigación de diferentes ciencias, inclusive de la geografía, foco de este artículo. Se destaca la tendencia histórica de la geografía a analizar temas diversos, condicionados a las nuevas racionalidades del espacio. Así, buscando ampliar la cooperación entre investigadores (turismólogos y geógrafos) se define como objetivo general mapear los estudios (tesis y disertaciones) que optan por el turismo como tema de investigación en el ámbito de los programas brasileños de posgrado stricto sensu en geografía, y analizar la relevancia de la temática del turismo en esos estudios. Se destaca el carácter exploratorio-analítico permeado por un abordaje cualitativo, destacándose el relevamiento bibliográfico y el análisis de contenido como herramientas técnicas. Los resultados exponen un total de 814 estudios (tesis y disertaciones) que optan por la temática del turismo en el ámbito del posgrado stricto sensu en geografía en Brasil. 491 estudios eligieron el turismo como temática central de la investigación y 323 estudios trataron el turismo de forma complementaria. Se concluye que el turismo como temática para estudios (tesis y disertaciones) de los programas brasileños de posgrado stricto sensu en geografía presenta relevancia, y la geografía continúa destacándose como una de las ciencias que más fomenta estudios a partir de la relación académica con el turismo. Se proyecta que los estudios de las cuestiones problematizadas avancen en número y en complejidad.

Abstract Purpose To evaluate PBS®MCIMMO cement in the filling of bone defects. Methods Thirty-six adult male Wistar rats were divided into three groups of twelve individuals each (group 1, group 2 and group 3). In all groups, a bone failure in the femur was induced, 2.0 mm wide and 7.0 mm deep. In group 1, the PBS®MCIMMO cement was applied to the bone defect produced and a titanium implant (CONNECTION®) 1.5 mm thick and 6 mm long was installed. In group 2, only the PBS® CIMMO cement was installed. In group 3, only bone failure was performed. Kruskal Wallis tests were performed to compare the mean area among the three groups. Results In all comparisons, significance was observed for group 2 (p = 0.0014–0.0026). Conclusion The PBS®CIMMO cement induced bone neoformation, and integration between the newly formed bone, cement, and implant was observed.

RESUMO Objetivo: Avaliar o efeito da meditação no nível de estresse psicológico de mulheres com neoplasia mamária. Método: Revisão sistemática da literatura, realizada nas bases de dados LILACS, PubMed, Scopus, CINAHL e Web of Science. Resultados: A amostra foi composta de 22 estudos que empregaram as técnicas Mindfulness, Meditação Transcendental, Meditação Contemplativa de autocura. Verificou-se efeito significativo da meditação na redução do nível de estresse, nos sintomas de estresse pós-traumático, autorrelato de estresse e estresse crônico. Em alguns estudos, o efeito esteve associado à redução do cortisol e ao aumento da telomerase. Conclusão: A meditação apresentou efeitos positivos na redução de sintomas físicos e emocionais, como o estresse psicológico, depressão, ansiedade, fadiga, medo de recorrência e ruminação, representando estratégia eficiente para enfrentamento da doença e melhoria da qualidade de vida.

ABSTRACT Objective: To evaluate the effect of meditation on the psychological stress level of women with breast cancer. Method: A systematic literature review performed in the LILACS, PubMed, Scopus, CINAHL and Web of Science databases. Results: The sample consisted of 22 studies using Mindfulness, Transcendental Meditation, and Contemplative Self-Healing Meditation techniques. There was a significant effect of meditation on stress reduction, post-traumatic stress symptoms, self-reported stress, and chronic stress verified. In some studies, the effect was associated with decreased cortisol and increased telomerase. Conclusion: Meditation has shown positive effects in reducing physical and emotional symptoms such as psychological stress, depression, anxiety, fatigue, fear of recurrence and rumination, representing an efficient strategy for coping with the disease and improving quality of life.

RESUMEN Objetivo: Evaluar el efecto de la meditación en el nivel de estrés psicológico de mujeres con neoplasia mamaria. Método: Revisión sistemática de la literatura, realizada en las bases de datos LILACS, PubMed, Scopus, CINAHL y Web of Science. Resultados: La muestra estuvo compuesta de 22 estudios que emplearon las técnicas Mindfulness, Meditación Transcendental, Meditación Contemplativa de autocuración. Se verificó efecto significativo de la medicación en la reducción del nivel de estrés, los síntomas de estrés postraumático, autorrelato de estrés y estrés crónico. En algunos estudios, el efecto estuvo asociado con la reducción del cortisol y el aumento de la telomerasa. Conclusión: La meditación presentó efectos positivos en la reducción de síntomas físicos y emotivos, como el estrés psicológico, depresión, ansiedad, fatiga, miedo de recidiva y rumiación, representando estrategia eficiente para enfrentamiento de la enfermedad y mejoría de la calidad de vida.

ABSTRACT Aedes aegypti is one of the most important culicidae species for public health, since it transmits the viruses for yellow fever, dengue fever, chikungunya and zika. With the purpose of analyzing the effect of plant extracts on the oviposition of this vector in ovitraps, 100 ovitraps were set containing an attractive plant substrate and a pressed wooden palette vertically installed on the pot for female oviposition. The traps were randomly distributed in 10 neighborhoods of Crato, Ceará, Brazil. To determine the best extract, water from the supply network, distilled water, sewage and aqueous extracts of plant leaves from guava (Psidium guajava L.), papaya (Carica papaya L), cassava (Manihot esculenta Grantz), cashew tree (Anacardium occidentale L.), sorghum (Sorghum bicolor L., Moench) and grass hay (Cynodon nlemfluensis Vanderyst) were used. The substrates were prepared at the Laboratory of Agricultural Entomology at the Center of Agricultural Sciences and Biodiversity of the Federal University of Cariri (UFCA). Leaves were collected from the plants and crushed using a blender and then mixed with water at a concentration of 50 g of each substrate per liter of water. The material was stored for seven days in a dark room to facilitate the reactions and avoid the photoinactivation of active compounds. To determinate the best concentration, guava leaves were used subject to the same treatment of the first experiment, at concentrations of 0.5, 1; 5, 10, 25, 50, and 75 g of substrate per liter of water. Traps with sewage water showed the highest attractiveness for the oviposition of A. aegypti and the extract of guava leaves showed the highest percentage of egg attractiveness for the vector mosquito. These results can be useful to guide the adoption of new entomological surveillance and control methods of A. aegypti.

RESUMEN Aedes aegypti es una de las especies de culícidos más importantes para la salud pública, pues es transmisor de los virus de la fiebre amarilla, dengue, chikungunya y zika. Intentando analizar el efecto de extractos vegetales sobre la ovoposición de ese vector en trampas de ovoposición, fueron instaladas 100 trampas conteniendo en su interior sustrato atrayente de un vegetal y una paleta de madera prensada insertada en la posición vertical de la pared del vaso para que la hembra realice la postura. Las trampas fueron distribuidas, al azar, en 10 barrios de Crato-CE. Para determinar el mejor extracto fueron utilizadas agua de la red de suministro, agua destilada, desagüe y extractos acuosos de las hojas del guayabo (Psidium guajava L.), papayo (Carica papaya L.), mandioca (Manihot esculenta Crantz), anacardo (Anacardium occidentale L.), sorgo (Sorghum bicolor L., Moench) y heno de la gramínea (Cynodon nlemfluemsis Vanderyst). Los sustratos fueron preparados en el Laboratorio de Entomología Agrícola, en el Centro de Ciencias Agrarias y de Biodiversidad (CCAB), de la Universidad Federal de Cariri (UFCA). Las hojas fueron extraídas de la planta y enseguida, trituradas en una licuadora y mezcladas con agua en concentración de 50 g de cada sustrato por litro de agua. El material pasó siete días en ambiente oscuro para facilitar las reacciones y evitar la foto inactivación de los ingredientes activos. Para determinar la mejor concentración fueron utilizadas hojas del guayabo sometidas a las mismas etapas del primer experimento, aplicadas en las concentraciones de 0,5; 1; 5; 10; 25; 50 y 75 g del sustrato por litro de agua. Trampas cebadas con agua de desagüe manifiestan mayor atractividad para la ovoposición del A. aegypti y el extracto de la hoja del guayabo presenta mayor porcentaje de atractividad de huevos del mosquito vector. Estos resultados pueden ser útiles para orientar la adopción de métodos de vigilancia entomológica con ovotrampas y control del A. aegypti.

Abstract Background: Little has been published about the epidemiology of Granulomatosis with polyangiitis (GPA) in South America, especially in the intertropical zone, and no epidemiological data from Brazil are available. The purpose of the present study was to draw a clinical and demographic profile of GPA patients living in Northeastern Brazil based on laboratory, histological and imaging findings, and evaluate the frequency of organic involvement. Methods: Clinical, epidemiological and treatment data of GPA patients were collected retrospectively and compared with the literature. Results: The cohort included 25 GPA patients (84% female) aged 45.8 ± 16.1 years. Renal and ear-nose-throat (ENT) manifestations were the most common (both 64%). One third (32%) of the patients had 24-h proteinuria > 1 g, 50% had creatinine clearance < 50 mL/min at the time of diagnosis, and 33% had recurrent kidney damage during disease progress. The affected organs included lungs (60%), joints (44%), skin (32%), peripheral nervous system (28%), eyes (28%) and heart (16%). ENT involvement (n = 16/64%) was less frequent in our region than in São Paulo (n = 115/85.8%). Renal (n = 16/64%) and pulmonary (n = 15/60%) involvement was less frequent in our region than in the U.K. (renal n = 30/90%; pulmonary n = 28/84.8%). Conclusion: Most of our patients were female, presented the generalized form and were diagnosed late. The frequency of the main clinical manifestations (ENT, renal and pulmonary) was lower than that observed at higher latitudes, suggesting the existence of a Northeast Brazilian clinical and epidemiological profile and adding to our knowledge of this rare condition.

Aedes aegypti L. is the most important mosquito in terms of public health in the world. It transmits a virus that causes several diseases, among them, dengue fever. Traditionally, the intensive use of insecticides has been the main strategy to control A. aegypti and to eliminate adult mosquitos or their larvae; however, this may lead to resistance by the mosquitos and damages to human health and the environment. Essential oils from medicinal plants have shown high efficiency as alternative larvicides. Therefore, the objective of this paper was to evaluate the larvicide potential of Vanillosmopsis arborea and Hyptis suaveolens on Aedes aegypti larvae. The essential oils were extracted by the hydrodistillation method using a Clevenger equipment. The completely randomized design (CRD) was used with a 2x5 factorial, with two essential oils and five concentration levels (200; 150; 100; 50; and 0 ppm). Each one of the ten treatments was replicated four times with ten larvae each, totaling 40 plots. Analyses were made regarding LC10, LC50, LC90, test of means, and regression and efficiency analysss. The V. arborea oil showed values of LC W = 39.69 ppm, LC50 = 48.98 ppm, and LC90 = 60.45 ppm, while the H. suaveolens oil showed values of LC W = 78.46 ppm, LC50 = 139.7 ppm and LC90 = 246.48 ppm. The main chemical component of V. arborea was a-bisabolol (94.17%), while for H. suaveolens, it was 1,8-cineol (72.23%). The essential oils showed a larvicide effect on A. aegypti larvae

Aedes aegypti L. es el mosquito de salud pública más importante del mundo. Esto es debido a que es un transmisor del virus que causa muchas enfermedades, específicamente el dengue. Tradicionalmente, el uso intensivo de insecticidas ha sido la estrategia principal para eliminar los mosquitos adultos o sus larvas; Sin embargo el uso intensivo de insecticidas puede estimular una resistencia en los mosquitos y daños a la salud o al medio ambiente. Los aceites esenciales de plantas medicinales se habían mostrado de alta eficiencia como larvicidas alternativos. Por lo tanto, evaluamos la eficiencia de los aceites esenciales de Vanillosmopsis arborea y Hyptis suaveolens en larvas de Aedes aegypti. Los aceites esenciales se extrajeron mediante el método de hidrodestila-ción utilizando un equipo Clevenger. Se utilizó un diseño completamente al azar (CRD) utilizando un factorial 2x5 que el aceite esencial de V. arborea y H. suaveolens a concentraciones de cinco concentraciones (200, 150, 100, 50 y 0 ppm) respectivamente. Cada uno de los diez tratamientos se replicó cuatro veces utilizando diez larvas cada uno, totalizando 40 muestras. CL W CL50, CL(9)0, ensayo promedio, análisis de regresión y eficiencia. El aceite de V. arborea mostró valores de CL W = 39,69 ppm, CL50 = 48,98ppm y CL90 = 60,45 ppm, mientras que el aceite de H. suaveolens mostró valores de CL W = 78,46ppm, CL50 = 139,7 ppm y CL90 246,48 ppm. El principal componente químico de V. arborea fue a-bisabolol (94,17%), mientras que para H. suaveolens fue 1,8-cineol (72,23%). Ambos aceites esenciales probados mostraron efecto larvicida sobre las larvas de A. aegypti